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    Methods. A literature review was conducted to obtain all publications pertaining to routine-dose tadalafil. The search terms used on PubMed included tadalafil, ED, daily dosing, routine dosing, and Cialis.Manuscripts were identified and selected based on their relevance to the subject matter of daily dose tadalafil.

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    Cialis for Once Daily Use for BPH and for ED and BPH. In three placebo-controlled clinical trials of 12 weeks duration, two in patients with BPH and one in patients with ED and BPH, the mean age was 63 years (range 44 to 93) and the discontinuation rate due to adverse events in patients treated with tadalafil was 3.6% compared to 1.6% in placebo-treated patients.


    Most erectile dysfunction medications, including Cialis, are not designed for the daily use when taken at the dosage required to help you get an erection.Normally, it is necessary to plan ahead and take an erectile dysfunction tablet an hour to 30 minutes before sex in order to benefit from the treatment.

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    As an on-demand treatment, PDE5Is have excellent efficacy and safety in the treatment of ED due to a broad spectrum of etiologies.
    The NCBI web site requires JavaScript to function.
    Journal List Drug Des Devel Ther v.
    Copyright 2010 Washington and Shindel, publisher and licensee Dove Medical Press Ltd.
    This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

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    This article has been cited by other articles in PMC. Abstract Selective phosphodiesterase type 5 inhibitors (PDE5Is) have revolutionized the treatment of erectile dysfunction (ED) in men.
    Nevertheless, these drugs do have side-effect profiles that are troublesome to some patients, eg, headache, dyspepsia, myalgia, etc.
    Furthermore, many patients and their partners dislike the necessity of on-demand treatment for ED, citing a desire for greater spontaneity with sexual interactions.
    In this study, we review the current state of the art with respect to this new management strategy for ED, highlighting published reports of the efficacy and tolerability of the daily dose tadalafil regimen.
    Keywords: PDE5 inhibitor, on-demand therapy, side effects, daily dosing Introduction Erectile dysfunction (ED) is defined as the persistent and/or recurrent inability to attain and/or maintain a penile erection sufficient for satisfactory sexual intercourse.
    ED is associated with substantial psychological distress for both men and their partners and has been clearly linked to cardiovascular health problems both as a comorbid condition and as a sentinel event for serious vascular diseases in the future.
    In this modern era, selective phosphodiesterase type 5 inhibitors (PDE5Is) are the mainstay of treatment for ED. 6 These medications are highly efficacious, are well tolerated, and have very favorable safety profiles.
    Another PDE5I, udenafil, has been approved for use in South Korea, and a number of novel PDE5Is are currently in various stages of development.

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